Mathematical Modeling of the Nutrient Medium Composition for the Production of Yeast Phytase


1 University of Food Technology, Department of Automation, Information and Operation Equipment, BG - 4002 Plovdiv, Bulgaria
2 Plovdiv University “P. Hilendarski”, Department of Biochemistry and Microbiology, BG - 4000 Plovdiv, Bulgaria
3 University of Food Technology, Department of Biotechnology, BG - 4002 Plovdiv, Bulgaria


STANCHEV, V., D. GEORGIEV and S. GARGOVA, 2010. Mathematical modeling of the nutrient medium composition for the production of yeast phytase. Bulg. J. Agric. Sci., 16: 628-634

The objective of the present study was the optimization of the nutrient medium composition for Candida melibiosica 2491 cultivation by means of mathematical methods of modeling and production of yeasts with higher enzyme capacity. An optimal composition plan was used for the mathematical description of the process that enabled the generation of linear and non-linear regression models with a minimum number of trial observations. The mathematical modeling resulted in a new composition of the nutrient medium for the phytase biosynthesis of C. melibiosica, namely: (g/dm3) fructose – 30.0; yeast extract – 5.0; meat peptone – 8.71 and KH2PO4 – 0.2 mmol, achieving an increase of cell phytase productivity with 22.5%.

Key words: mathematical modeling, yeasts, phytase, nutrient medium

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