Subchronic Toxicity Study of Ethanol Infusion from Cotinus Coggygria Wood in Rats

D. IVANOVA, D. PAVLOV, M. EFTIMOV, K. KALCHEV, M. NASHAR, M. TZANEVA and S. VALCHEVA-KUZMANOVA
Medical University “Prof. Dr. Paraskev Stoyanov”, BG – 9002 Varna, Bulgaria

Abstract

Ivanova, D., D. Pavlov, M. Eftimov, K. Kalchev, M. Nashar, M. Tzaneva and S. Valcheva-Kuzmanova, 2013. Subchronic toxicity study of ethanol infusion from Cotinus coggygria wood in rats. Bulg. J. Agric. Sci., Supplement 2, 19: 182–185

 

Cotinus coggygria is considered to be a poisonous plant, however there are data from traditional medicine indicating an internal use of plant infusions. The aim of this study was to examine the subchronic toxicity of ethanol infusion from C. coggygria wood in experimental animals. Three groups of 10 male Wistar rats were treated by stomach gavage for 30 days as follows: (1) distilled water, (2) 20% ethanol, (3) 20% ethanol infusion from wood at doses of 10 ml/kg b.w. Biochemical results showed that the treatment with ethanol infusion from C. coggygria wood did not cause subchronic toxicity on liver, kidney or brain. Histological investigation did not detect pathological deviations in the organs of the treated group as compared to both controls. Therefore, C. coggygria does not exhibit toxicity and may be used for further study of effects in vivo.

Key words: Cotinus coggygria, histopathology, biochemical markers, toxicology

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