Interaction of Cells with Modified Polyethylenglycol Surfaces

A. KOSTADINOVA1, N. ZAEKOV1 and I. KERANOV2

1 BAS, IBBME, Department of Electro induced Effects in Biomembranes, BG – 1113 Sofia, Bulgaria
2 Centre de Recherche Public Henri Tudor, Department of Advanced Materials and Structures, Esch-sur-Alzette, Luxembourg

Abstract

Kostadinova, A., N. Zaekov and I. Keranov, 2013. Interaction of cells with modified polyethylenglycol surfaces. Bulg. J. Agric. Sci., Supplement 2, 19: 178–181

 

The uses of a polymer as biomaterials, contacting with the living tissue, blood, proteins and other biological fluids inside or outside of the human body requires solving serious problems with biocompatibility. The problems could be overcome with appropriate polymer surface modification, introducing various functional groups, positively charged, negatively charged and uncharged. The aim of this work is to improve the surface bio-compatibility of hydrophobic poly (dimethylsiloxane) (PDMS), using plasma treatment followed by acrylic acid grafting with different density and PEG coupling with different density and chain length. The maximum of cell adhesion and proliferation on the surface with an average density of PEG were observed.

Key words: Tissue Engineering, cell attachment, biomaterials, PEG, PDMS
Abbreviations: PDMS – poly (dimethylsiloxane), PEG – Polyetilenglicol, FN – fibronectin, XPS – X-ray photoelectron spectroscopy

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