Effect of Simultaneous Application of Vitamins B1 and C on Thiol Antidotes in Lead Poisoning

A. ANGELOV1, Hr. HRISTEV1, L. BELCHEV1 and M. CHICHOVSKA2
1Veterinary Station, BG-4000 Plovdiv, Bulgaria
2Medical University, BG-4000 Plovdiv, Bulgaria

Abstract

ANGELOV, A., Hr. HRISTEV, L. BELCHEV and M. CHICHOVSKA, 2003. Effect of simultaneous application of vitamins B1 and C on thiol antidotes in lead poisoning. Bulg. J. Agric. Sci., 9: 401–406

The effect of simultaneous application of vitamins B1 and C, separately or in combination, on the therapeutic results of a-mercapto/2-furyl/acrylic acid (MFA) and 2.3 dimercaptosuccinic acid (DMSA) was studied. The simultaneous application of vitamins B1 and C with MFA or DMSA, separately or in combination, increases lead excretion with urine. The highest lead concentration in urine was established in the group treated with MFA and DMSA. The results of the group treated with vitamin C and DMSA were found closest to control in terms of d-aminolevulinate dehydrogenase and hematocrit. The administration of DMSA along with vitamin B1 and C, separately or in combination, strongly reduces kidney lead content.

Key words: ascorbic acid (vitamin C), thiamin (vitamin B1), lead, α-mercapto/2-furyl/acrylic acid, 2,3 dimercaptosuccinic acid