Studies on the Therapeutic Effect of Cloxacillin in Dogs with Experimental Staphylococcal Infection

D. DIMITROVA, I. BORISSOV, M. ANDONOVA, D. PASHOV, D. DIMITROV, P. SOTIROVA and M. KOLEVA
Trakia University, Faculty of Veterinary Medicine, BG-6000 Stara Zagora, Bulgaria

Abstract

DIMITROVA, D., I. BORISSOV, M. ANDONOVA, D. PASHOV, D. DIMITROV, P. SOTIROVA and M. KOLEVA, 2002. Studies on the therapeutic effect of cloxacillin in dogs with experimental staphylococcal infection. Bulg. J. Agric. Sci., 8: 103–110

The therapeutic effect of cloxacillin sodium was studied in 6 dogs, 3 of both genders aged 2­years and weighing 13 ± 2 kg, experimentally infected via subcutaneous injection of 108 colony forming cells/ml broth culture of Staphylococcus aureus (field strain). The changes in clinical parameters (body temperature, heart and respiratory rates, general condition) and some laboratory indices (haematocrit, haemoglobin, red blood cell (RBC) counts, erytrocyte sedimentation rate (ESR), total and differrential white blood cell (WBC) counts, index of phagocytic activity, phagocytic number, total protein and protein fractions, fibrinogen, urea, creatinine) were followed out after the experimental staphylococcal infection and treatment with cloxacillin.
It was observed that i.m. applied cloxacillin led to normalization of changes in the clinical condition and the laboratory parameters observed during the development of the aerobic infection. A high efficacy (83.4%) was achieved following 7-day application of the antibiotic. It was determined that cloxacillin at a dose of 78 mg/kg b.w. applied at 8 hour intervals, was suitable for the treatment of soft tissue and dermatological infections caused by S. aureus.

Key words: Staphylococcus aureus, experimental infection, dogs, cloxacillin