Effects of Acetylsalicylic Acid on Adrenal Response in Lambs Exposed to Transport and New Environment

D. GUDEV, S. POPOVA-RALCHEVA, I. YANCHEV, L. KOZELOV and P. MONEVA
Research Institute of Animal Science, BG-2232 Kostinbrod, Bulgaria

Abstract

GUDEV, D., S. POPOVA-RALCHEVA, I. YANCHEV, L. KOZELOV and P. MONEVA, 2002. Effects of acetylsalicylic acid on adrenal response in lambs exposed to transport and new environment. Bulg. J. Agric. Sci., 8: 433–438

In this study we examined the possibility for reduction of adrenal response in 4 acetylsalicylic acid pretreated upper-mountainous lambs, exposed to transport and accommodated in a new environment. Lambs were allocated into two groups – control (n = 4) and experimental (n = 4). Experimental lambs were given acetylsalicylic acid before the transportation and 3rd day following the accommodation in a unfamiliar animal unit.
Plasma cortisol, glucose and lactate levels were measured immediately after the transportation (1st day) and 3, 6 and 9 days following the accommodation of the lambs in the new environment.
An ethological observation was conducted of the end of the experiment (11th day).
Acetylsalicylic acid reduced plasma cortisol (P < 0.05) and glucose (P > 0.05) at 3rd day following the transportation. There were no sizable differences in plasma lactate levels between control and experimental lambs.
Bearing reflexes in 57.14% of the lambs turned into stable defensive behaviour while the rest of the animals showed fluctuating food behaviour.

Key words: adrenal glands, transport stress, cortisol, environment, acetylsalicylic acid
Abbreviations: HPA – hypothalamic-pituitary-adrenal, ACTH – adrenocortioctropin, CRH – corticotropin-releasing hormone, AVP – arginine vasopresin