Effect of Acetylsalicylic Acid on Adrenal Response to Immobilization and Adrenocorticotropin Administration in Goats

D. GUDEV, S. POPOVA-RALCHEVA, S. ALEXANDROV and P. MONEVA
Institute of Animal Science, BG-2232 Kostinbrod, Bulgaria

Abstract

GUDEV, D., S. POPOVA-RALCHEVA, S. ALEXANDROV and P. MONEVA, 2001. Effect of Acetylsalicylic acid on adrenal response to immobilization and adrenocorticotropin administration in goats. Bulg. J. Agric. Sci., 7: 645-648

Seven local goats were exposed to stress by immobilization (50 min) or by injection of adrenocorticotropin (Synacthen Depot – 5 μg/kg b.w.). The animals were subjected to stress with or without prior administration of aspirin (Acetylsalicylic acid -1250 mg) dissolved in 20 ml distilled water and given to each goat to drink. The intensity of the adrenal response to stress was assessed by the level of cortisol in peripheral blood, taken at fixed intervals.
Aspirin was given 3 h before the exposure to stress.
It was established that:
- prior administration of aspirin reduces the immobilization stress – induced enhancement of cortisol level in goats
- aspirin does not affect adrenal response to stress. Therefore the effect of aspirin on HPA takes place at central level (pituitary or hypothlamus).

Key words: stress, ACTH, immobilization, aspirin, cortisol
Abbreviations: ACTH – adrenocorticotropin, HPA axis – hypothalamic-pituitary-adrenal axis, CRH – corticotropin releasing hormone, AVP – arginine vasopressin